منابع مشابه
Lamins
Xie and Burke discuss the roles of lamins in nuclear morphology and the pathological consequences of defects in these nuclear envelope proteins.
متن کاملDisruption of spermatogenesis in mice lacking A-type lamins.
Nuclear lamins are structural protein components of the nuclear envelope. Mutations in LMNA, the gene coding for A-type lamins, result in several human hereditary diseases, the laminopathies, which include Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy, familial partial lipodystrophy and Hutchinson-Gilford progeria. Similar to the human conditions, it has been shown that Lmna(-/-) mi...
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The presence of paranoid thoughts is not exclusive to clinical disorder; recent data suggest that their prevalence follows an exponential-shaped curve, with many people experiencing a few such thoughts, while a few people experience many such thoughts. Wong et al (pp. 221–229) found that this exponential curve was also evident in their assessment of paranoid thoughts in children, but the freque...
متن کاملA Comparative Study of Drosophila and Human A-Type Lamins
Nuclear intermediate filament proteins, called lamins, form a meshwork that lines the inner surface of the nuclear envelope. Lamins contain three domains: an N-terminal head, a central rod and a C-terminal tail domain possessing an Ig-fold structural motif. Lamins are classified as either A- or B-type based on structure and expression pattern. The Drosophila genome possesses two genes encoding ...
متن کاملNurturing the genome: A-type lamins preserve genomic stability.
A-type lamins provide a scaffold for tethering chromatin and protein complexes regulating nuclear structure and function. Interest in lamins increased after mutations in the LMNA gene were found to be associated with a variety of human disorders termed laminopathies. These include muscular dystrophy, cardiomyopathy, lipodystrophy, peripheral neuropathy and premature aging syndromes such as prog...
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ژورنال
عنوان ژورنال: Journal of Structural Biology
سال: 2020
ISSN: 1047-8477
DOI: 10.1016/j.jsb.2019.10.006